Rutin NF11/EP8/DAB10

RUTIN (Sophora japonica extract)

Rutinraw

English name: Flos sophorae immaturus, Japanese pagodatree flower-bud Synonym: Meletin, sophoretin Origin: The flower bud of sophora japonica L Plant morphology: Deciduous tree with height of about 15-25meters Collecting and processing: Collect the flower bud in summer, drying timely, removing the branches, stems and impurities Appearance: The shape of flower bud is oval, with length of 2-6mm, diameter of about 2mm Odorless, slightly bitter taste Chemical composition: Contains rutin, saponin and sterol Property and Flavor: Slightly cold in nature, bitter taste Indications: Cooling blood and hemostasis, purging liver fire, for the treatment of hemafecia, hemorrhoidal bleeding, blood dysentery, uterine bleeding, hematemesis, epistaxis, conjunctival hyperemia caused by hepatopyretic disease, headache and dizziness Dosage: 4 5-9g

Rutin Products
Product name: Rutin
Synonym: Rutoside, Vitamin P, Violaquereitrin
Chemical Name: 
3-{[6-0-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy}-2-(3, 4-dihyroxyphenyl)-5, 7-dihydroxy-4H-1-benzopyran-4-one. 
Molecular Structure: 

M. F. & M. W.: C27H30O16; 610.51
Physical Property: Yellowish- needle - crystal (in water); M. P.: 176-8°C, 23D: +13.82°C (ethanol), 20D-39.43 °C (pyridine); Solubility: 1g in 7ml of methanol, 8000ml of water, 200ml of boiling water; UVλ CH3OHmax nm: 258.361; IRνKBr max cm-1: 3400(OH), 1670(C=O), 1620, 1520, 1470(C6H5-). 
Plant source: Ruta graveolens L., plant essential oil [2]; Sophora japonica L., main part of fruit [3, 4]; Hypericum aseyron L., full plant; Berchemia polyphylla Wall, var leioclada Hand. -Mazz. [5]; Mallotus japonicus Muell. -Arg, leafs [6]; Fagopyrum esculentum Moench seedling. 
Indications: 
1. Anti-inflammatory action: Apparent suppression of inflammation due to planted wool when the product is injected into abdominal cavity of rat [8]. Sodium rutin sulfate has very strong anti-inflammatory action to edema of rat [9]. 
2. Actions like Vitamin P: Maintain the strength of blood vessel, reduce its permeability and brittleness; Degreasing action to liver fatty infiltration, especially together with glutathione. 
3. Antiviral action: Best suppression to phlyctenular stomatitis virus at product concentration of 200g/ml [10, 11]. 
4. Inhibition of aldehyde reductase: 95% inhibition at a concentration of 10-5M [12], which facilitates the treatment of diabetic cataract. 
5. Toxicity: Mice, intravenous injection, LD50 at 950mg/kg. 
6. Clinical use: For the prevention of intracerebral hemorrhage, hypertension, retinal hemorrhage, purpura and acute hemorrhagic nephrosonephritis; For treatment of chronic tracheitis with effective rate at 84.8% and 98%. Its derivative, troxerutin, or Venoruton, is applied clinically for burn, arthritis, and all kinds of blood vessel diseases. Commodity drug is available in abroad [14], while the drug has been successfully developed in domestic. With Effective rate for the treatment of cerebrovascular diseases is 87.8%; 88% for retinal edema and hemorrhage

Specification of Rutin (NF11) 
Specification of Rutin (EP8.0) 
Specification of Rutin (DAB10) 

Product Name: Rutin Botanical source: Sophorae Japonica Part of plant used: Flower CAS #: 153-18-4
TEST	DAB10	TEST METHOD
Appearance Melting point Identification(A/B/C) Purity Insoluble Matter -Solution(a) -Solution(b) Particle size Related Substances Isoquercetin Quercetin Kaempferol 3-Rutinoside Bluk Density Tapped Density Heavy metals -Arsenic -Mercury -Cadmium -Lead Ash Loss on drying Assay(on dry basis)	Light greenish yellow powder 210ºC melting and decompositon Must positive Must Conforms Should be clarified Should be clarified 95% pass through 80 mesh Must Conforms ≤2.0% ≤2.0% ≤2.0% ≥0.30GM/cc ≥0.50GM/cc ≤10ppm ≤1ppm ≤0.1ppm ≤1ppm ≤3ppm ≤0.10% 5.5%-8.5% 98.0%-102.0%	Visual Infrared Absorption pH Meter US Screen UV UV HPLC CP2010 CP2010 Visual Colorimetry AAS AAS AAS AAS CP2010 120ºC UV